One form of vitamin B3 is effective against an incurable disease
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Scientists at the University of Helsinki have found that a form of vitamin B3 is effective against an incurable cellular disease, intractable mitochondrial dysfunction.
Science Advances notes that mitochondrial dysfunction is both hereditary and acquired. This disease is characterized by dysfunction of mitochondria, the main energy resource of cells. When infected with this disease, the mitochondria stop producing the adenosine triphosphate molecule, and the person feels constant weakness and fatigue, and psychological disorders develop. This disease is currently untreatable and not well understood.
Researchers have found that nicotinamide riboside (NR)- (a pyridine nucleoside and a form of vitamin B₃ or NAD+), when taken long-term, can have beneficial effects on human muscle mitochondria. In addition, NR improves the gut microbiome and increases the concentration of NAD+ in the blood, which is an important molecule for mitochondria.
To this end, the researchers studied samples of blood, fat, muscle and stool taken from identical twins before and after the use of HP. The positive effect of this substance was noted in both lean and obese twins.
Nicotinamide riboside increases differentiation (turning on and off certain cellular genes) of muscle stem cells and improves genetic diversity, including methyl groups in DNA.
Researchers believe that this form of vitamin B3 may be an effective and promising treatment option for diseases characterized by disruption of the gut microbiome and muscle mitochondrial dysfunction.
Source: Linta. EN