‘Smart’ surgical knife that detects uterine cancer in ‘seconds’
Scientists announce smart surgical knife that can detect when it has penetrated cancerous tissue, with a “reliable” diagnosis of uterine cancer “within seconds”.
The iKnife device has been shown in previous studies to be a revolutionary tool in the diagnosis of various types of cancer, which can pinpoint exactly what tissue needs to be removed from a patient, reducing surgery time and the need for reoperations.
📢 NEW RESEARCH📢 iKnife can reliably diagnose endometrial cancer and help thousands of healthy women recover faster
– Appeal the day before (@eveappeal) January 4, 2023
Thanks@eveappealfor funding this work Point-of-care diagnosis of endometrial cancer using a surgical smart knife (iKnife)@athenalamnisos1 @ImperialSandC @RCObsGynThanks@Diana_Marcushttps://t.co/V7tG0Xchrw
– Sadaf Gaem-Magami 💙 (@SadafSadaf14) November 29, 2022
Previous research has shown that a smart knife — a type of electrosurgical knife used to cut and cauterize blood vessels — can correctly identify different tissue types, including the lungs, colon and liver.
iKnife, bisturí que ‘huele’ los tumors, es capaz de Detectar Cancer de útero en segundos – Business Insider España https://t.co/LlvlidvuGQ
Asikome Universal (@Asikomeapp) January 4, 2023
Research has shown that iKnife works by absorbing smoke during cauterization in a mass spectrometer, a device that reads chemical signatures and indicates whether cut tissue is cancerous or healthy.
“The results are very encouraging and suggest that iKnife can be used in the clinic to provide medical assistance in diagnosis” https://t.co/2hxM7DDihM
— Kudach United Kingdom (@QudachUK) January 4, 2023
“iKnife is a novel tool that uses standard electrosurgery techniques to generate surgical aerosols, which are then interpreted by mass spectrometers to provide real-time tissue signatures,” scientists, including those from Imperial College London, explained in a study published in magazine. Crayfish.
In the new study, the scientists sought to determine whether iKnife could correctly identify endometrial cancer from biopsy samples.
Scientists say endometrial cancer is a common gynecological cancer, with more than 120,000 new cases diagnosed each year in the European Union alone.
The team evaluated about 150 endometrial samples in this study and found that the smart knife “reliably” diagnoses endometrial cancer in seconds with an accuracy of about 90%.
“These results are very encouraging and indicate that the iKnife can be used in the clinic for point-of-care diagnostics,” the scientists noted, adding that the surgical instrument could pave the way for “new diagnostic avenues.”
So far, scientists say, analyzing tissue samples to diagnose uterine cancer can “take up to two weeks,” with delays in treatment and definitive surgery negatively impacting chances of survival.
Using the iKnife, which has been shown to “accurately distinguish” between normal and cancerous tissue in a variety of tumors, including colon, breast, cervical and ovarian tissue, the team says they can develop a rapid method for diagnosing endometrial cancer.
They added that the smart knife technology “could speed up the patient journey by providing point-of-care diagnosis for women with suspected endometrial cancer. It accurately distinguishes normal from malignant endometrial tissue based on differences in their lipid profiles.” The scientists added that more research is needed to test this method and improve its diagnostic performance.