The temperature in our bodies has been falling for 160 years, a study has revealed a possible reason for this!
The average human body temperature has steadily declined since the mid-19th century, and scientists don’t know why.
The new study suggests one important factor that may play a role: gut microbes.
By studying data from hospitalized patients with sepsis, in which the body reacts very dangerously to infection, as well as tests done on mice, the researchers studied the relationship between gut bacteria, changes in temperature, and health. results.
This selection of patients with sepsis is deliberate because the condition can lead to various fluctuations in body temperature, which are often associated with a person’s chances of recovery and recovery.
“We know that temperature response is important in sepsis because it accurately predicts who will live and who will die,” says microbiologist and immunologist Robert Dixon of the University of Michigan. “But we don’t know what causes this difference and whether it can be modulated to help patients.”
The team studied gut bacteria samples taken from 116 people with sepsis and found that there are large differences in the microbiota, and that these differences are associated with changes in patients’ temperature trajectories.
Firmicutes bacteria have been most closely associated with heat. These bacteria produce substances important for the growth and health of the body and influence the body’s immune response and metabolism.
While it’s not enough to show that our gut bacteria are the reason we’ve been cold inside for the past 150 years, it’s an interesting hypothesis that shows how the gut microbiome is related to body temperature.
“We can say that our patients have more differences in the microbiota than in the genes,” says GP Callie Bongers from the University of Michigan. .” 0% in intestinal bacteria.
In further testing of healthy mice with and without the bacterial microbiome, animals without bacteria showed lower core body temperatures, while antibiotic treatment also reduced body temperatures in mice.
What’s more, the same family of bacteria in humans and mice appears to be associated with temperature fluctuations. The next step will be to study more samples from a wider range of people and develop the biological mechanisms that underlie this relationship.
It is possible that with further research, we may be able to develop ways to specifically modify the gut microbiome to influence body temperature, which in turn could improve the prospects for treating people with conditions such as sepsis.
“There’s a reason why temperature is a vital indicator,” says Bongers. “It’s easy to measure and gives us important information about the body’s inflammatory and metabolic state.”
The study was published in the American Journal of Respiratory and Critical Care Medicine.
Source: Science Alert