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What is the link between early menopause and Alzheimer’s disease risk?

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It is estimated that women are more likely to develop Alzheimer’s than men, as they make up about two-thirds of people with the disease.

A recent study showed that early menopause may increase the risk of Alzheimer’s disease.

American researchers have found that the earlier women go through menopause, the more likely they are to suffer from amnesia.

The longer the period between the onset of menopause and the start of HRT, the higher the chances of infection.

The researchers said that women who took the drug’s biosimilar five years after menopause had higher amounts of tau in the brain, a protein associated with the disease.

“When it comes to hormone therapy, timing is everything,” says Dr. Joanne Manson of Brigham and Women’s Hospital.

Dr. Rachel Buckley of the Department of Neurology at Massachusetts General Hospital added: “HRT is the most reliable way to relieve severe menopausal symptoms. But over the past few decades, there has been a lack of clarity about how HRT affects the brain. .”

She continued: “We found that the highest levels of tau, a protein associated with Alzheimer’s disease, were only seen in women on hormone therapy who reported a long delay between the age of menopause and the start of hormone therapy. tau deposition may underlie a link between delayed intervention in hormone therapy and Alzheimer’s disease that we have never seen before.”

Premature menopause, defined as menopause occurring spontaneously before age 40 or following surgery before age 45, is associated with an increased risk of developing Alzheimer’s disease, the most common dementia. HRT can relieve many of the severe symptoms associated with menopause and should also prevent cognitive impairment.

Previous research has shown that HRT may reduce the risk of Alzheimer’s disease in some women.

The results of a new study published in the journal JAMA Neurology show how menopause and HRT can affect the risk of this condition.

The researchers analyzed brain scans of 292 adults who did not have dementia to see how amyloid and tau proteins associated with Alzheimer’s disease accumulated in their brains.

Women had higher levels of tau than men of the same age, and those who went through early menopause had more of both proteins.

Levels were higher in parts of the brain associated with memory, which are known to be associated with Alzheimer’s disease.

And women who took HRT at least five years after menopause also had more protein.

Dr Sarah Imaricio of the Alzheimer’s Research Center in the UK said: “HRT offers important benefits for many women as it helps combat the symptoms that menopause can cause.”

How menopause and hormone therapy affects the brain is still unclear, the researchers said, and more research is needed.

Source: Sun

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